A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes.

@article{Michalek2007ANS,
  title={A numerical study to determine pericellular matrix modulus and evaluate its effects on the micromechanical environment of chondrocytes.},
  author={Arthur J. Michalek and James C Iatridis},
  journal={Journal of biomechanics},
  year={2007},
  volume={40 6},
  pages={1405-9}
}
Chondrocyte biosynthesis is highly sensitive to mechanical strain. A thin pericellular matrix (PCM) surrounds the cell and plays an important role in mechanotransduction. PCM material properties are difficult to measure directly because of its size and connectivity to both cell and extracellular matrix (ECM). The purpose of this study was to develop a method of calculating linear elastic properties of the PCM using an inverse finite element approach with experimental properties of cell and… CONTINUE READING