A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels.

@article{Hallaq2004ANM,
  title={A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels.},
  author={Haifa Hallaq and Emese Pinter and Josephine M. Enciso and James McGrath and Caroline J. Zeiss and Martina Brueckner and Joseph A. Madri and Harris C. Jacobs and Christine M. Wilson and Hemaxi Vasavada and Xiaobing Jiang and Clifford W Bogue},
  journal={Development},
  year={2004},
  volume={131 20},
  pages={5197-209}
}
The homeobox gene Hhex has recently been shown to be essential for normal liver, thyroid and forebrain development. Hhex(-/-) mice die by mid-gestation (E14.5) and the cause of their early demise remains unclear. Because Hhex is expressed in the developing blood islands at E7.0 in the endothelium of the developing vasculature and heart at E9.0-9.5, and in the ventral foregut endoderm at E8.5-9.0, it has been postulated to play a critical role in heart and vascular development. We show here, for… CONTINUE READING

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