A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism.

@article{Bonen2007ANM,
  title={A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism.},
  author={Arend Bonen and Xiao-xia Han and Daphna D. J. Habets and Maria Febbraio and Jan F. C. Glatz and Joost J. F. P. Luiken},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 6},
  pages={E1740-9}
}
Fatty acid translocase (FAT)/CD36 is involved in regulating the uptake of long-chain fatty acids into muscle cells. However, the contribution of FAT/CD36 to fatty acid metabolism remains unknown. We examined the role of FAT/CD36 on fatty acid metabolism in perfused muscles (soleus and red and white gastrocnemius) of wild-type (WT) and FAT/CD36 null (KO) mice. In general, in muscles of KO mice, 1) insulin sensitivity and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) sensitivity… CONTINUE READING