A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism.

@article{Binas2003ANM,
  title={A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism.},
  author={Bert Binas and Xiao-xia Han and Erdal Erol and Joost J. F. P. Luiken and Jan F. C. Glatz and David James Dyck and Rafat Motazavi and Peter J Adihetty and David A. Hood and Arend Bonen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={285 3},
  pages={E481-9}
}
The low-molecular-mass, cytosolic heart-type fatty acid-binding protein (H-FABP) is thought to be required for shuttling FA through the cytosol. Therefore, we examined the effects of an H-FABP-null mutation on FA and carbohydrate metabolism in isolated soleus muscle at rest and during a period of increased metabolic demand (30-min contraction). There were lower concentrations of creatine phosphate (-41%), ATP (-22%), glycogen (-34%), and lactate (-31%) (P < 0.05) in H-FABP-null soleus muscles… CONTINUE READING
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