A nucleotide dimer synthesis without protecting groups using montmorillonite as catalyst.

@article{Joshi2012AND,
  title={A nucleotide dimer synthesis without protecting groups using montmorillonite as catalyst.},
  author={Prakash C. Joshi and Michael Frank Aldersley and Dmitri V. Zagorevskii and James P. Ferris},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2012},
  volume={31 7},
  pages={
          536-66
        }
}
A synthesis has been developed providing nucleotide dimers comprising natural or unnatural nucleoside residues. A ribonucleoside 5'-phosphorimidazolide is added to a nucleoside adsorbed on montmorillonite at neutral pH with the absence of protecting groups. Approximately 30% of the imidazolide is converted into each 2'-5' dimer and 3'-5' dimer with the rest hydrolyzed to the 5'-monophosphate. Experiments with many combinations have suggested the limits to which this method may be applied… CONTINUE READING
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