A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.

@article{Brandl1990ANS,
  title={A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.},
  author={Christopher J Brandl and Kevin Struhl},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 8},
  pages={4256-65}
}
In the gal-his3 hybrid promoter his3-GG1, the yeast upstream activator protein GCN4 stimulates transcription when bound at the position normally occupied by the TATA element. This TATA-independent activation by GCN4 requires two additional elements in the gal enhancer region that are distinct from those involved in normal galactose induction. Both additional elements appear to be functionally distinct from a classical TATA element because they cannot be replaced by the TFIID-binding sequence… CONTINUE READING
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Molecular mechanisms of transcriptional regulation in yeast

  • G. Thireos, H. Greer
  • Annu . Rev . Biochem .
  • 1989

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