A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer.

@article{Hwang2010ANM,
  title={A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer.},
  author={Do Won Hwang and Hae Young Ko and Jung Hwan Lee and Hyungu Kang and Sung Ho Ryu and In Chan Song and Dong Soo Lee and Soonhag Kim},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2010},
  volume={51 1},
  pages={98-105}
}
UNLABELLED The recent advances in molecular imaging techniques, using cancer-targeting nanoparticle probes, provide noninvasive tracking information on cancer cells in living subjects. Here, we report a multimodal cancer-targeted imaging system capable of concurrent fluorescence imaging, radionuclide imaging, and MRI in vivo. METHODS A cobalt-ferrite nanoparticle surrounded by fluorescent rhodamine (designated MF) within a silica shell matrix was synthesized with the AS1411 aptamer (MF-AS1411… CONTINUE READING
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