A nuclease-hypersensitive element of the human c-myc promoter interacts with a transcription initiation factor.

@article{Postel1989ANE,
  title={A nuclease-hypersensitive element of the human c-myc promoter interacts with a transcription initiation factor.},
  author={Edith Horn Postel and Susan E Mango and Stephanie Flint},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 11},
  pages={
          5123-33
        }
}
Transcription of the human c-myc oncogene is elaborately regulated, but the relevant molecular mechanisms are not yet understood. To begin to define elements and enzyme systems responsible for c-myc transcription in vitro, we partially purified a transcription factor essential for efficient and accurate in vitro initiation from the principal myc promoter, P2. DNA mobility shift assays located the factor binding domain at -142 to -115 with respect to the P1 promoter. This region contains pur/pyr… CONTINUE READING
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