A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements.

@article{Burnside1990ANF,
  title={A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements.},
  author={Joan Burnside and Douglas S. Darling and William Wei Lim Chin},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 5},
  pages={2500-4}
}
Recent studies from this laboratory have demonstrated the presence of thyroid hormone response elements (TREs) in the 5'-flanking region of the rat alpha and TSH beta subunit genes. Using an avidin-biotin complex DNA binding assay, we have shown that these TREs bind the thyroid hormone (T3) receptor present in nuclear extracts of GH3 cells, as well as the in vitro synthesized Hc-erbA beta, which has been identified as a member of the family of T3 receptors. The binding of Hc-erbA beta to the… CONTINUE READING

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