A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.

@article{Akira1990ANF,
  title={A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.},
  author={Shizuo Akira and Hiroshi Isshiki and Takahisa Sugita and O Tanabe and Shigemi M. Kinoshita and Yukihiro Nishio and Tomomi Nakajima and Toshio Hirano and Tadamitsu Kishimoto},
  journal={The EMBO Journal},
  year={1990},
  volume={9}
}
NF‐IL6 is a nuclear factor that specifically binds to an IL1‐responsive element in the IL‐6 gene. In this study the gene encoding NF‐IL6 has been cloned by direct screening of a lambda gt11 library using NF‐IL6 binding sequence as a ligand. The full‐length cDNA encoded a 345 amino acid protein with a potential leucine zipper structure and revealed a high degree of homology to a liver‐specific transcriptional factor, C/EBP, at the C‐terminal portion. The bacterial fusion protein bound to the… Expand
NF-IL6 Knockout Mice
Nuclear factor for IL-6 expression (NF-IL6) was originally identified as a nuclear factor binding to a 14-bp palindromic sequence (ACATTGCACAATCT) within an interleukin (IL)-1 responsive element inExpand
Roles of CCAAT/enhancer‐binding protein in transcriptional regulation of the human IL‐5 gene
TLDR
It is found that ectopic expression of NF‐IL6 (C/EBPβ) increases endogenous IL‐5 mRNA expression and the data suggest that C/E BP proteins may regulateIL‐5 gene expression in response to different stimulation signals. Expand
Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL‐6 through its basic‐leucine zipper domain
TLDR
Results indicate that HBx alters the DNA‐binding affinity of NF‐IL6 through the direct interaction between the C‐terminal domain of HBx and the basic region‐leucine zipper domain of NF-IL6. Expand
C/EBP homologous protein (CHOP) up‐regulates IL‐6 transcription by trapping negative regulating NF‐IL6 isoform
TLDR
Evidence is provided that CHOP up‐regulates the IL‐6 transcription without binding to its promoter, probably by trapping protein(s) such as LIP, which would otherwise inhibit IL‐ 6 transcription. Expand
Activation of the TSG-6 Gene by NF-IL6 Requires Two Adjacent NF-IL6 Binding Sites (*)
TLDR
It is concluded that the two NF-IL6 sites are functionally interdependent in the activation of the TSG-6 gene. Expand
NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A.
TLDR
Results identify NF-IL6 as a sequence-specific cellular nuclear factor which regulates E1A-responsive genes in the absence of E1B, consistent with these functions. Expand
A NF‐κB p65 subunit is indispensable for activating manganese superoxide: Dismutase gene transcription mediated by tumor necrosis factor‐α
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Results show that a NF‐κB p65 subunit is mainly involved in the molecular mechanisms controlling TNF‐α‐mediated Mn‐SOD gene transcription. Expand
Transcription factor NF-IL6 (C/EBPbeta) activates the expression of the mouse MHC class I H2-Kb gene in response to TNF-alpha via the intragenic downstream regulatory element.
  • J. Hatina, P. Jansa, J. Reischig
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2002
TLDR
It is concluded that the H2-K(b) gene belongs to target genes of the NF-IL6 (C/EBPbeta) in the course of the cellular response to TNF-alpha, and some consequences of this conclusion are discussed in a general framework of inducible expression of the H1N1 gene. Expand
NF-IL6 (C/EBPβ) Vigorously Activates il1b Gene Expression via a Spi-1 (PU.1) Protein-Protein Tether*
TLDR
Transient transfection assays, using mutated il1b core promoters, showed that the Spi-1, but not the NF-IL6, binding site is absolutely required for functional cooperativity, and that the TAD transactivation domain (TAD) is functionally indispensable and more critical than that of Spo-1. Expand
Opposing roles of activator protein‐1 and CCAAT/enhancer binding protein β in the regulation of inducible granulysin gene expression in a human monocytic cell line, THP‐1
TLDR
The results suggest that the gene expression of granulysin in macrophages would be exquisitely regulated by positive and negative transcription factors when microbial invasion occurs, and the Toll‐like receptor 2‐dependent signalling pathway may be involved in A. laidlawii‐induced transactivation of the granuly sin promoter. Expand
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