A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells

@inproceedings{Vert2016ANH,
  title={A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells},
  author={Anna Vert and Jessica Castro and Marc Ribo and Antoni Benito and Maria Vilanova},
  booktitle={Oncotarget},
  year={2016}
}
Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members of the vertebrate secreted ribonuclease family are not cytotoxic because they are not able to evade the cytosolic ribonuclease inhibitor. We previously engineered the human pancreatic ribonuclease to direct it to the cell nucleus where the inhibitor is not present. The best characterized variant is PE5 that kills cancer cells through apoptosis mediated by the p21(WAF1/CIP1) induction and the… CONTINUE READING
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