A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae.

@article{Kuai2005AND,
  title={A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae.},
  author={Letian Kuai and Biswadip Das and Fred Sherman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 39},
  pages={13962-7}
}
We previously demonstrated an increased degradation of mRNAs in mutants of Saccharomyces cerevisiae having blocks in nuclear export. The degradation activity, designated DRN (degradation of mRNA in the nucleus), requires Cbc1p, a nuclear cap-binding protein, and Rrp6p, a nuclear exosome component. Microarray procedures were used to determine the half-lives of mRNAs from normal and mutant strains, leading to the tentative identification of hundreds of normal mRNAs that were notably stabilized… CONTINUE READING

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