A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans

@article{Zischler1995AN,
  title={A nuclear 'fossil' of the mitochondrial D-loop and the origin of modern humans},
  author={Hans Zischler and Helga Geisert and Arndt von Haeseler and Svante P{\"a}{\"a}bo},
  journal={Nature},
  year={1995},
  volume={378},
  pages={489-492}
}
MAMMALIAN mitochondria! DNA sequences evolve more rapidly than nuclear sequences1. Although the rapid rate of evolution is an advantage for the study of closely related species and populations, it presents a problem in situations where related species, used as outgroups in phylogenetic analyses, have accumulated so much change that multiple substitutions obliterate the phylogenetic information2. However, mitochondrial DNA sequences are frequently inserted into the nuclear genome3, where they… CONTINUE READING