A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.

@article{Gizard2001ANZ,
  title={A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.},
  author={Florence Gizard and Bernard Lavall{\'e}e and Fr{\'e}d{\'e}rique Dewitte and Dean W. Hum},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={33881-92}
}
The human CYP11A1 gene is expressed specifically in steroidogenic tissues and encodes cytochrome P450scc, which catalyzes the first step in steroid synthesis. A region of the 5'-flanking DNA of the gene from nucleotides -155 to -131 (-155/-131) is shown to activate transcription in steroidogenic human placental JEG-3 (1) and adrenal NCI-H295 cells. Using this region of the gene as probe, a cDNA clone of 4.4 kilobase pairs was isolated by screening JEG-3 cell and human placental cDNA expression… CONTINUE READING

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