A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.

  • J. Joshua Yang
  • Published 2003 in
    Biochemical and biophysical research…


ZAK has been implicated in cell cycle arrest regulation through its function on decreasing cyclin E expression. To explore the mechanistic basis for this regulation, the yeast two-hybrid system was used with a novel Krüppel-type C2H2 zinc finger member cloned. This cloned cDNA encodes a novel protein with Krüppel-type zinc fingers designed as ZZaPK (zinc… (More)


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