A novel visible spectrophotometric method for the determination of ethamsylate in pharmaceutical preparations and biological samples.

@article{Zhang2010ANV,
  title={A novel visible spectrophotometric method for the determination of ethamsylate in pharmaceutical preparations and biological samples.},
  author={Meiyun Zhang and Yan Zhang and Quan-min Li},
  journal={Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
  year={2010},
  volume={75 3},
  pages={1013-7}
}
A highly sensitive visible spectrophotometric method has been developed to determine ethamsylate in this paper, which is based on using Cu(II) as spectroscopic probe reagent. The study indicates that in the presence of SCN(-) and KNO(3), Cu(II) is reduced to Cu(I) by ethamsylate at pH 5.0, and the in situ formed Cu(I) reacts with SCN(-) to form into the white emulsion CuSCN that could be stayed upon the surface of water. According to the amount of residual Cu(II), the amount of ethamsylate can… CONTINUE READING