A novel viral oncogene with structural similarity to phospholipase C

@article{Mayer1988ANV,
  title={A novel viral oncogene with structural similarity to phospholipase C},
  author={Bruce J Mayer and Michinari Hamaguchi and Hidesaburo Hanafusa},
  journal={Nature},
  year={1988},
  volume={332},
  pages={272-275}
}
Numerous oncogenes have been isolated from acutely transforming retroviruses. To date, the products of these viral oncogenes have been protein kinases, nuclear proteins, growth factors, or GTP-binding proteins1,2. We have cloned the previously uncharacterized avian sarcoma virus CT10 and sequenced its genome. This virus encodes a protein, p47gag-crk, that has blocks of sequence similarity to the amino-terminal, non-catalytic region of the non-receptor class of tyrosine kinases. In addition, the… CONTINUE READING