A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient


SR designed and performed experiments, wrote the first draft of the manuscript, contributed to revisions of the paper, and approved the final submitted version. CC provided input into experimental design, performed experiments, and reviewed and approved the final version of the manuscript. DJ and XM assisted in design of experiments, performed the… (More)
DOI: 10.1038/leu.2012.46


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