A novel variational Bayes multiple locus Z-statistic for genome-wide association studies with Bayesian model averaging

@article{Logsdon2012ANV,
  title={A novel variational Bayes multiple locus Z-statistic for genome-wide association studies with Bayesian model averaging},
  author={Benjamin A. Logsdon and Cara L. Carty and Alexander P. Reiner and James Y. Dai and Charles L. Kooperberg},
  journal={Bioinformatics},
  year={2012},
  volume={28 13},
  pages={
          1738-44
        }
}
MOTIVATION For many complex traits, including height, the majority of variants identified by genome-wide association studies (GWAS) have small effects, leaving a significant proportion of the heritable variation unexplained. Although many penalized multiple regression methodologies have been proposed to increase the power to detect associations for complex genetic architectures, they generally lack mechanisms for false-positive control and diagnostics for model over-fitting. Our methodology is… CONTINUE READING

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