A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer.

@article{Wang2008ANV,
  title={A novel variable number of tandem repeats (VNTR) polymorphism containing Sp1 binding elements in the promoter of XRCC5 is a risk factor for human bladder cancer.},
  author={Shouyu Wang and Meilin Wang and Shiwei Yin and Guangbo Fu and Chunping Li and Rui Chen and Aiping Li and Jianwei Zhou and Zhengdong Zhang and Qizhan Liu},
  journal={Mutation research},
  year={2008},
  volume={638 1-2},
  pages={
          26-36
        }
}
X-ray repair cross-complementing 5 (XRCC5) is a gene involved in repair of DNA double-strand breaks. Abnormal expression of the XRCC5 protein is associated with genomic instability and an increased incidence of cancers. In our study, a polymorphism with a variable number of tandem repeats (21-bp repeat elements at position -201 to -160 relative to the initiation of transcription) in the promoter of XRCC5 was identified. As determined with gel-shift and super-shift assays, the binding affinity… CONTINUE READING

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