A novel urinary metabolite signature for diagnosing major depressive disorder.

@article{Zheng2013ANU,
  title={A novel urinary metabolite signature for diagnosing major depressive disorder.},
  author={Peng Zheng and Jianjun Chen and Ting Huang and Ming-ju Wang and Ying Wang and Mei-xue Dong and Yuan-jun Huang and Lin-ke Zhou and Peng Xie},
  journal={Journal of proteome research},
  year={2013},
  volume={12 12},
  pages={5904-11}
}
Major depressive disorder (MDD) is a prevalent and debilitating mental disorder. Yet, there are no objective biomarkers available to support diagnostic laboratory testing for this disease. Here, gas chromatography-mass spectrometry was applied to urine metabolic profiling of 126 MDD and 134 control subjects. Orthogonal partial least-squares discriminant analysis (OPLS-DA) was used to identify the differential metabolites in MDD subjects relative to healthy controls. The OPLS-DA analysis of data… CONTINUE READING
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