A novel upstream element compensates for an ineffectual octamer motif in an immunoglobulin V kappa promoter.

@article{Atchison1990ANU,
  title={A novel upstream element compensates for an ineffectual octamer motif in an immunoglobulin V kappa promoter.},
  author={Michael L Atchison and Vmncent Delmas and R. P. Perry},
  journal={The EMBO journal},
  year={1990},
  volume={9 10},
  pages={3109-17}
}
The octamer (or dc/cd) motif is considered to be a critical component of all immunoglobulin (Ig) promoters. Although the sequence of this motif is highly conserved among most Ig promoters, there are some notable examples in which efficiently expressed Ig genes contain divergent octamers with base substitutions that are demonstrably deleterious when tested with heterologous proximal promoter elements. To elucidate the mechanisms that enable these naturally occurring Ig genes to cope with… CONTINUE READING

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