A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene.

@article{Johnson2009ANT,
  title={A novel type of p53 pathway dysfunction in chronic lymphocytic leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene.},
  author={Gillian G. Johnson and Paul D. Sherrington and Anthony P. Carter and Ke Jen Lin and Triantafillos Liloglou and John K. Field and Andrew R. Pettitt},
  journal={Cancer research},
  year={2009},
  volume={69 12},
  pages={5210-7}
}
The ATM-p53 pathway plays an important role in the biology of chronic lymphocytic leukemia (CLL). Its functional integrity can be probed by exposing CLL cells to ionizing radiation (IR) and measuring levels of p53 protein and one of its transcriptional targets, the cyclin-dependent kinase inhibitor p21. We have previously identified two abnormal p53/p21 response patterns associated with inactivating mutations of TP53 and ATM, respectively. Here, we describe a third abnormal response pattern… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 56 references

Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia

TEPHAN, TILGENBAUER, ONSTANZE, ÖHNER
2010
View 1 Excerpt

Clinical and biological features of CLL patients with the type C defect Normal p53 response

E Wattel, C Preudhomme, B Hecquet
IgVH mutation, • 2009

ZAP-70 h. 4, 2017

JA Orchard, RE Ibbotson, Z Davis
2009

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