A novel type of PTD, common helix-loop-helix motif, could efficiently mediate protein transduction into mammalian cells.

@article{Chen2006ANT,
  title={A novel type of PTD, common helix-loop-helix motif, could efficiently mediate protein transduction into mammalian cells.},
  author={Jing Chen and Ge Li and Jun Lyu and Lei Chen and Yin Huang and Huiling Wu and Jiaxin Zhang and Daru Lu},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={347 4},
  pages={931-40}
}
Protein transduction domains (PTDs), such as HIV TAT PTD, have been widely used as delivery tools into living cells. Here we reported for the first time that the helix-loop-helix (HLH) domain of basic helix-loop-helix (bHLH) family was a novel type of PTD. Efficient internalization has been obtained with HLH domains derived from bHLH proteins, NeuroD/BETA2, Neurogenin3, and Mitf, in various cell types including stable cell lines and primary cells. Cellular uptake of HLH PTD was barely or… CONTINUE READING

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