A novel two-dimensional electrophoresis technique for the identification of intrinsically unstructured proteins.

@article{Csizmok2006ANT,
  title={A novel two-dimensional electrophoresis technique for the identification of intrinsically unstructured proteins.},
  author={Veronika Csizmok and Edit Szollosi and P{\'e}ter Friedrich and Peter Tompa},
  journal={Molecular & cellular proteomics : MCP},
  year={2006},
  volume={5 2},
  pages={265-73}
}
Intrinsically unstructured proteins (IUPs) lack a well defined three-dimensional structure under physiological conditions. They constitute a significant fraction of various proteomes, but only a handful of them have so far been identified. Here we report the development of a two-dimensional electrophoresis technique for their de novo recognition and characterization. This technique consists of the combination of native and 8 m urea electrophoresis of heat-treated proteins where IUPs are… CONTINUE READING
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