A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma

  title={A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma},
  author={L. Li and Y. Li and X. Li and C. Zhang and Y. Zhou and S. Lu},
  journal={BMC Cancer},
  pages={52 - 52}
  • L. Li, Y. Li, +3 authors S. Lu
  • Published 2010
  • Biology, Medicine
  • BMC Cancer
  • BackgroundThe esophageal carcinoma related gene 4 (ECRG4) was initially identified and cloned from human normal esophageal epithelium in our laboratory (GenBank accession no.AF325503). ECRG4 has been described as a novel tumor suppressor gene associated with prognosis in esophageal squamous cell carcinoma (ESCC).MethodsIn this study, binding affinity assay in vitro and co-immunoprecipitation experiment in vivo were utilized to verify the physical interaction between ECRG4 and transmembrane… CONTINUE READING
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