A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.

@article{Nunes2011ANT,
  title={A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.},
  author={Cl{\'a}udia Trindade Nunes and Kelly L. Miners and Garry Dolton and Chris Pepper and Christopher Fegan and Malcolm David Mason and Stephen Man},
  journal={Cancer research},
  year={2011},
  volume={71 16},
  pages={5435-44}
}
Cancer cells frequently exhibit defects in apoptosis, which contribute to increased survival and chemotherapeutic resistance. For example, genetic mutations or abnormal proteasomal degradation can reduce expression of Bax which limits apoptosis. In cancers where abnormal proteasomal degradation of Bax occurs, we hypothesized that Bax peptides that bind to human leukocyte antigen (HLA) class I molecules would be generated for presentation to CD8(+) T cells. To test this hypothesis, we generated… CONTINUE READING
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