A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions.

@article{Allan2001ANT,
  title={A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions.},
  author={Charles M. Allan and Miriam C. Haywood and Seshapillai Swaraj and Jenny A. Spaliviero and Adam Koch and Mark Jimenez and Matti Poutanen and J{\'e}r{\^o}me Levallet and I lpo Huhtaniemi and Peter Illingworth and David J Handelsman},
  journal={Endocrinology},
  year={2001},
  volume={142 6},
  pages={2213-20}
}
Gonadal function is wholly reliant on the two pituitary-derived gonadotropins, FSH and LH. Identifying the specific effects of FSH has been difficult because of the intimate relationship between LH and FSH action and inherent limitations of classic research paradigms. We describe a novel transgenic model to characterize the definitive actions of FSH alone, distinct from LH effects, created by combining transgenic FSH expression with the gonadotropin-deficient background of the hypogonadal (hpg… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
GonadotropinsChemical structure ofUrofollitropin
We describe a novel transgenic model to characterize the definitive actions of FSH alone , distinct from LH effects , created by combining transgenic FSH expression with the gonadotropin - deficient background of the hypogonadal ( hpg ) mouse .
Gonadal function is wholly reliant on the two pituitary - derived gonadotropins , FSH and LH .
Gonadal structureIs associated anatomy of gene productGonadotropins
Gonadal function is wholly reliant on the two pituitary - derived gonadotropins , FSH and LH .
A novel transgenic model to characterize the specific effects of follicle - stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions .
In addition , ovaries of FSHxhpg females were enlarged up to 10-fold ( P < 0.001 ) , characterized by increased follicular recruitment and development to type 7 antral follicles .
In addition , ovaries of FSHxhpg females were enlarged up to 10-fold ( P < 0.001 ) , characterized by increased follicular recruitment and development to type 7 antral follicles .
In addition , ovaries of FSHxhpg females were enlarged up to 10-fold ( P < 0.001 ) , characterized by increased follicular recruitment and development to type 7 antral follicles .
A novel transgenic model to characterize the specific effects of follicle - stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions .
A novel transgenic model to characterize the specific effects of follicle - stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions .
A novel transgenic model to characterize the specific effects of follicle - stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions .
A novel transgenic model to characterize the specific effects of follicle - stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions .
Histology of enlarged FSHxhpg testes revealed round spermatids and sparse numbers of elongated spermatids , demonstrating that the testosterone - independent FSH response targeting the Sertoli cell can facilitate completion of meiosis and minimal initiation , but not completion , of spermiogenesis .
Histology of enlarged FSHxhpg testes revealed round spermatids and sparse numbers of elongated spermatids , demonstrating that the testosterone - independent FSH response targeting the Sertoli cell can facilitate completion of meiosis and minimal initiation , but not completion , of spermiogenesis .
Gonadal function is wholly reliant on the two pituitary - derived gonadotropins , FSH and LH .
We describe a novel transgenic model to characterize the definitive actions of FSH alone , distinct from LH effects , created by combining transgenic FSH expression with the gonadotropin - deficient background of the hypogonadal ( hpg ) mouse .
A novel transgenic model to characterize the specific effects of follicle - stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions .
All Topics