A novel transforming gene in a human malignant melanoma cell line

@article{Padua1984ANT,
  title={A novel transforming gene in a human malignant melanoma cell line},
  author={Rodolfo A. Padua and Nigel Charles Barrass and Graham A. Currie},
  journal={Nature},
  year={1984},
  volume={311},
  pages={671-673}
}
Cellular transforming genes can be detected in human tumours by DNA-mediated transfection into NIH 3T3 mouse fibroblasts1,2. The activated transforming genes have been, in most cases, members of the ras gene family, of which the most frequently found is the c-Ki-ras oncogene3–7 and least frequently the c-Ha-ras gene8–10. An increasing number of studies has identified the presence of activated N-ras (which has no known viral homologue) in human tumour cell lines11–18. Furthermore, other… CONTINUE READING
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