A novel transfecting peptide comprising a tetrameric nuclear localization sequence

@article{Ritter2003ANT,
  title={A novel transfecting peptide comprising a tetrameric nuclear localization sequence},
  author={Wolfgang Ritter and Christian Plank and James Lausier and Carsten Rudolph and Daniela Zink and Dietrich Reinhardt and Joseph Rosenecker},
  journal={Journal of Molecular Medicine},
  year={2003},
  volume={81},
  pages={708-717}
}
The transport of exogenous DNA into the nucleus of eukaryotic cells is a prerequisite for successful gene delivery. To favor nuclear transport we synthesized a tetramer of the nuclear localization signal (NLS) of the SV40 large T-antigen as a novel nonviral gene delivery vector. This 4.4-kDa lysine-rich peptide (NLSV404) binds and compacts DNA by electrostatic interaction and forms stable polyplexes. Apart from its sequence-specific potency to mediate nuclear accumulation of conjugated albumin… CONTINUE READING

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