A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C.

@article{Amimoto2007ANT,
  title={A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C.},
  author={Katsuhiko Amimoto and Taichi Noro and Eiji Oishi and Mitsugu Shimizu},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 4},
  pages={
          1198-206
        }
}
An unknown cytotoxin was identified in the culture supernatant of Clostridium perfringens type C. The cytotoxin, named TpeL, which was purified using mAb-based affinity chromatography, had a lethal activity of 62 minimum lethal dose (MLD) mg(-1) in mice and a cytotoxic activity of 6.2x10(5) cytotoxic units (CU) mg(-1) in Vero cells. The nucleotide sequence of TpeL was determined. The entire ORF had a length of 4953 bases, and the same nucleotide sequence was not recorded in the GenBank/EMBL… CONTINUE READING

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