A novel temperature-responsive polymer as a gene vector.

  title={A novel temperature-responsive polymer as a gene vector.},
  author={Yongzheng Ma and Sen Hou and Bin Ji and Yang Yao and Xizeng Feng},
  journal={Macromolecular bioscience},
  volume={10 2},
A temperature-responsive polymer poly{2-(dimethylamino)ethyl methacrylate-co-[cis-butenedioic anhydride-poly[(N-isopropylacrylamide)-co-(butyl methacrylate)]]} (PDMNIB) was synthesized by free radical polymerization. The polymer had a significant temperature-responsive behavior with a lower critical solution temperature (LCST) at 20 degrees C. Gel retardation assay showed that PDMNIB could efficiently interact with DNA. Dynamic light scattering (DLS) and zeta potential measurement indicated… CONTINUE READING
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