A novel tau mutation, p.K317N, causes globular glial tauopathy

@article{Tacik2015ANT,
  title={A novel tau mutation, p.K317N, causes globular glial tauopathy},
  author={Pawel Tacik and Michael DeTure and Wen-lang Lin and Monica Y Sanchez Contreras and Aleksandra M. Wojtas and Kelly M. Hinkle and Shinsuke Fujioka and Matthew Douglas Baker and Ronald L. Walton and Yari Carlomagno and Patricia H. Brown and Audrey J. Strongosky and Naomi Kouri and Melissa E Murray and Leonard Petrucelli and Keith A. Josephs and Rosa Rademakers and Owen A. Ross and Zbigniew K Wszolek and Dennis W. Dickson},
  journal={Acta Neuropathologica},
  year={2015},
  volume={130},
  pages={199-214}
}
Abstract Globular glial tauopathies (GGTs) are 4-repeat tauopathies neuropathologically characterized by tau-positive, globular glial inclusions, including both globular oligodendroglial inclusions and globular astrocytic inclusions. No mutations have been found in 25 of the 30 GGT cases reported in the literature who have been screened for mutations in microtubule associated protein tau (MAPT). In this report, six patients with GGT (four with subtype III and two with subtype I) were screened… CONTINUE READING

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