A novel targeting drug carrier to deliver chemical bonded and physical entrapped anti-tumor drugs.

Abstract

In this study, we demonstrated a novel targeting drug carrier formed by amphiphilic prodrug based mixed micelle. Along with octadecyl chains, chemical bonded Dox moieties were utilized to entrap free drugs (PTX) and simultaneously acted as therapeutic agents. The formulation of CP-Folate/CPN=Dox/PTX showed spherical micellar structure and possessed high… (More)
DOI: 10.1016/j.ijpharm.2014.03.006

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