A novel system of peptidergic regulation.

  title={A novel system of peptidergic regulation.},
  author={Alexander A Karelin and Blishchenko EYu and Vadim T. Ivanov},
  journal={FEBS letters},
  volume={428 1-2},
Systematic analysis of structure and biological activity of peptide components of tissue extracts and biological fluids allows us to formulate a novel concept of a peptidergic regulatory system, complementary to the conventional regulatory systems (i.e. nervous, endocrine and paracrine systems). According to that concept, the proteolytic degradation of tissue proteins carried out by a specific and regulated system of tissue-specific enzymes and protein substrates gives rise to a large group of… CONTINUE READING
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