A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway.

@article{Lien2001ANS,
  title={A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway.},
  author={Egil Lien and Jesse C. Chow and Lynn D. Hawkins and Pamela Mcguinness and Katsuya Miyake and Terje Espevik and Fabi{\'a}n Gusovsky and Douglas T Golenbock},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 3},
  pages={
          1873-80
        }
}
ER-112022 is a novel acyclic synthetic lipid A analog that contains six symmetrically organized fatty acids on a noncarbohydrate backbone. Chinese hamster ovary (CHO)-K1 fibroblasts and U373 human astrocytoma cells do not respond to lipopolysaccharide (LPS) in the absence of CD14. In contrast, exposure to ER-112022 effectively induced activation of CHO and U373 cells under serum-free conditions. Expression of CD14 was not necessary for cells to respond to ER-112022, although the presence of… CONTINUE READING
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