A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

@article{Piazza2009ANS,
  title={A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.},
  author={Gary Anthony Piazza and Adam B. Keeton and Heather N Tinsley and Bernard D. Gary and Jason D. Whitt and Bini Mathew and Jose Thaiparambil and Lori Coward and Gregory H. Gorman and Yonghe Li and Brahma P. Sani and Judith Varady Hobrath and Yulia Y. Maxuitenko and Robert C. Reynolds},
  journal={Cancer prevention research},
  year={2009},
  volume={2 6},
  pages={
          572-80
        }
}
Nonsteroidal anti-inflammatory drugs such as sulindac have shown promising antineoplastic activity, although toxicity from cyclooxygenase (COX) inhibition and the suppression of prostaglandin synthesis limits their use for chemoprevention. Previous studies have concluded that the mechanism responsible for their antineoplastic activity may be COX independent. To selectively design out the COX inhibitory activity of sulindac sulfide (SS), in silico modeling studies were done that revealed the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 69 CITATIONS, ESTIMATED 63% COVERAGE

Amine Containing Analogs of Sulindac for Cancer Prevention

VIEW 3 EXCERPTS
CITES BACKGROUND

Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer

VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

NSAID activated gene (NAG-1), a modulator of tumorigenesis.

VIEW 1 EXCERPT

Differential binding mode of diverse cyclooxygenase inhibitors.

VIEW 1 EXCERPT

Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention

  • TA Chan
  • Lancet Oncol 2002;3:166–74
  • 2002
VIEW 1 EXCERPT