A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms.

@article{Hasegawa2007ANS,
  title={A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms.},
  author={Kimiko Hasegawa and Toshihiro Watanabe and Tomonori Suzuki and Akihito Yamano and Tetsuo Oikawa and Yasuhiko Sato and Hirokazu Kouguchi and Tohru Yoneyama and Koichi Niwa and Toshihiko Ikeda and Tohru Ohyama},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 34},
  pages={24777-83}
}
The botulinum neurotoxins (BoNTs) are the most potent toxins known in nature, causing the lethal disease known as botulism in humans and animals. The BoNTs act by inhibiting neurotransmitter release from cholinergic synapses. Clostridium botulinum strains produce large BoNTs toxin complexes, which include auxiliary non-toxic proteins that appear not only to protect BoNTs from the hostile environment of the digestive tract but also to assist BoNT translocation across the intestinal mucosal layer… CONTINUE READING

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