A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

Abstract

We previously reported that some systemic lupus erythematosus (SLE) patients have a population of circulating memory B cells with >2-fold higher levels of CD19. We show here that the presence of CD19(hi) B cells correlates with long-term adverse outcomes. These B cells do not appear anergic, as they exhibit high basal levels of phosphorylated Syk and ERK1/2… (More)

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@article{Nicholas2008ANS, title={A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.}, author={Matilda W Nicholas and Mary Anne Dooley and Susan Lynn Hogan and Jennifer H. Anolik and J. M. Looney and Ingnacio Sanz and Stephen Clarke}, journal={Clinical immunology}, year={2008}, volume={126 2}, pages={189-201} }