A novel subset of helper T cells promotes immune responses by secreting GM-CSF

@article{Zhang2013ANS,
  title={A novel subset of helper T cells promotes immune responses by secreting GM-CSF},
  author={J Zhang and Arthur I. Roberts and Cui-Yun Liu and Guangwen Ren and G Xu and L Zhang and Satish Devadas and Yufang Shi},
  journal={Cell Death and Differentiation},
  year={2013},
  volume={20},
  pages={1731-1741}
}
Helper T cells are crucial for maintaining proper immune responses. Yet, they have an undefined relationship with one of the most potent immune stimulatory cytokines, granulocyte macrophage-colony-stimulating factor (GM-CSF). By depleting major cytokines during the differentiation of CD4+ T cells in vitro, we derived cells that were found to produce large amounts of GM-CSF, but little of the cytokines produced by other helper T subsets. By their secretion of GM-CSF, this novel subset of helper… CONTINUE READING
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