A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide.

@article{Braet1998ANS,
  title={A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide.},
  author={Filip Braet and I. Spector and Ronald de Zanger and Eddie Wisse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={13635-40}
}
Hepatic endothelial fenestrae are dynamic structures that act as a sieving barrier to control the extensive exchange of material between the blood and the liver parenchyma. Alterations in the number or diameter of fenestrae by drugs, hormones, toxins, and diseases can produce serious perturbations in liver function. Previous studies have shown that disassembly of actin by cytochalasin B or latrunculin A caused a remarkable increase in the number of fenestrae and established the importance of… CONTINUE READING

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Braet et al

  • Kamps, J.A.A.M., +5 authors 11681–11685. 13640 Cell Biology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998
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