A novel strategy using G-CSF to support EMA/CO for high-risk gestational trophoblastic disease.

Abstract

EMA/CO (etoposide-methotrexate-actinomycin D and Cytoxan-Oncovin) is an effective and well-tolerated chemotherapy regimen for the treatment of high-risk gestational trophoblastic disease. However, it is associated with significant neutropenia often requiring dose reductions and treatment delays. We describe the use of granulocyte colony-stimulating factor (G-CSF) in three patients in order to maintain the treatment schedule. A subcutaneous injection of 5 micrograms/kg/day was administered on Days 3-6 and 9-14 of each chemotherapy cycle. No patients had any adverse effects and all received full chemotherapy doses without any treatment delay. The addition of G-CSF to the EMA/CO regimen may benefit patients by achieving dose intensity in the treatment of high-risk gestational trophoblastic disease.

Cite this paper

@article{Hartenbach1995ANS, title={A novel strategy using G-CSF to support EMA/CO for high-risk gestational trophoblastic disease.}, author={Ellen M Hartenbach and Alex K. Saltzman and Jason R Carter and Leo B. Twiggs}, journal={Gynecologic oncology}, year={1995}, volume={56 1}, pages={105-8} }