• DOI:10.1089/10430340460745766
Corpus ID: 20741916

A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.

@article{Ogawara2004ANS,
  title={A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.},
  author={Ken-ichi Ogawara and M. Rots and R. J. Kok and H. Moorlag and Anne-Miek van Loenen and D. Meijer and H. Haisma and G. Molema},
  journal={Human gene therapy},
  year={2004},
  volume={15 5},
  pages={
          433-43
        }
}

Ken-ichi Ogawara, M. Rots, +5 authors G. Molema

Published 2004

Biology, Medicine

Human gene therapy

To assess the possibilities of retargeting adenovirus to activated endothelial cells, we conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral capsid to inhibit the interaction between viral knob and coxsackie-adenovirus receptor (CAR). Subsequently, we introduced an alphav integrin-specific RGD peptide or E-selectin-specific antibody to the other functional group of the PEG molecule for the retargeting of the adenovirus to activated endothelial cells. In vitro studies showed… CONTINUE READING

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