A novel strategy for the treatment of cocaine addiction.

@article{Dewey1998ANS,
  title={A novel strategy for the treatment of cocaine addiction.},
  author={Stephen L. Dewey and Anthony E Morgan and Charles R. Ashby and Bryan A Horan and Stephanie A. Kushner and Jean Logan and Nora D. Volkow and Joanna S. Fowler and Eliot L. Gardner and Jonathan D. Brodie},
  journal={Synapse},
  year={1998},
  volume={30 2},
  pages={119-29}
}
Cocaine's addictive liability has been linked to its pharmacologic actions on mesotelencephalic dopamine (DA) reinforcement/reward pathways in the central nervous system (CNS). Dopaminergic transmission within these pathways is modulated by gamma-aminobutyric acid (GABA). With this knowledge, we examined the utility of gamma vinylGABA (GVG), a selective and irreversible inhibitor of GABA-transaminase (GABA-T) known to potentiate GABAergic inhibition, to alter cocaine's biochemical effects as… CONTINUE READING
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