A novel statin-mediated “prenylation block-and-release” assay provides insight into the membrane targeting mechanisms of small GTPases

@inproceedings{Ali2010ANS,
  title={A novel statin-mediated “prenylation block-and-release” assay provides insight into the membrane targeting mechanisms of small GTPases},
  author={Bassam R Ali and Ian Nouvel and Ka Fai Leung and Alistair N Hume and Miguel C. Seabra},
  booktitle={Biochemical and biophysical research communications},
  year={2010}
}
Ras super-family small GTPases regulate diverse cellular processes such as vesicular transport and signal transduction. Critical to these activities is the ability of these proteins to target to specific intracellular membranes. To allow association with membranes Ras-related GTPases are post-translationally modified by covalent attachment of prenyl groups… CONTINUE READING