A novel soluble supramolecular system for sustained rh-GH delivery.

@article{Salmaso2014ANS,
  title={A novel soluble supramolecular system for sustained rh-GH delivery.},
  author={Stefano Salmaso and Sara Bersani and Anna Scomparin and Anna Balasso and Chiara Brazzale and Michela Barattin and Paolo Caliceti},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={194},
  pages={168-77}
}
Methoxy-poly(ethylene glycol)s bearing a terminal cholanic moiety (mPEG(5kDa)-cholane, mPEG(10kDa)-cholane and mPEG(20kDa)-cholane) were physically combined with recombinant human growth hormone (rh-GH) to obtain supramolecular assemblies for sustained hormone delivery. The association constants (Ka) calculated by Scatchard analysis of size exclusion… CONTINUE READING