A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA.

@article{Fragapane1993ANS,
  title={A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA.},
  author={Paola Fragapane and Silvia Prislei and Alessandro Michienzi and Elisa Caffarelli and Irene Bozzoni},
  journal={The EMBO journal},
  year={1993},
  volume={12 7},
  pages={2921-8}
}
We report that the third intron of the L1 ribosomal protein gene of Xenopus laevis encodes a previously uncharacterized small nucleolar RNA that we called U16. This snRNA is not independently transcribed; instead it originates by processing of the pre-mRNA in which it is contained. Its sequence, localization and biosynthesis are phylogenetically conserved: in the corresponding intron of the human L1 ribosomal protein gene a highly homologous region is found which can be released from the pre… CONTINUE READING