A novel small molecule inhibitor of the DNA repair protein Ku70/80.

@article{Weterings2016ANS,
  title={A novel small molecule inhibitor of the DNA repair protein Ku70/80.},
  author={Eric Weterings and Alfred C Gallegos and Lauren N Dominick and Laurence S. Cooke and Trace N Bartels and Josef V{\'a}gner and Terry Onichi Matsunaga and Daruka Mahadevan},
  journal={DNA repair},
  year={2016},
  volume={43},
  pages={98-106}
}
Non-Homologous End-Joining (NHEJ) is the predominant pathway for the repair of DNA double strand breaks (DSBs) in human cells. The NHEJ pathway is frequently upregulated in several solid cancers as a compensatory mechanism for a separate DSB repair defect or for innate genomic instability, making this pathway a powerful target for synthetic lethality… CONTINUE READING

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