A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth

@inproceedings{Kaliszczak2013ANS,
  title={A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth},
  author={Maciej A. Kaliszczak and Sebastian Trousil and Ola {\AA}berg and Meg Perumal and Q-D Nguyen and Eric Ofori Aboagye},
  booktitle={British Journal of Cancer},
  year={2013}
}
Background:This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours.Methods:We evaluated the effect of a novel inhibitor, C1A, on HDAC6 biochemical activity and cell growth. We further examined potential of early noninvasive imaging of cell proliferation by [18F]fluorothymidine positron emission tomography ([18F]FLT-PET) to detect therapy response.Results:C1A induced sustained acetylation of HDAC6 substrates, α-tubulin and… CONTINUE READING