A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

@article{Cha2013ANS,
  title={A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo},
  author={Jieun R. C. Cha and Kyle J. H. St. Louis and Miranda L. Tradewell and Beno{\^i}t Jean Gentil and Sandra Minotti and Zahara M. Jaffer and Ruihong Chen and Allan E. Rubenstein and Heather D. Durham},
  journal={Cell Stress and Chaperones},
  year={2013},
  volume={19},
  pages={421-435}
}
Heat shock proteins (HSPs) are attractive therapeutic targets for neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), characterized by aberrant formation of protein aggregates. Although motor neurons have a high threshold for activation of HSP genes, HSP90 inhibitors are effective inducers. This study evaluated NXD30001, a novel, small molecule HSP90 inhibitor based on the radicicol backbone, for its ability to induce neuronal HSPs and for efficacy in an experimental model… CONTINUE READING
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